All participants had an initial Global Clinical Dementia Rating (CDR) Scale score ≤ 2, and neuropsychiatric symptoms were evaluated via the Neuropsychiatric Inventory-Questionnaire (NPI-Q). Participants completed annual research visits at the Northwestern University Alzheimer’s Disease Research Center.

In 44 participants with PPA or bvFTD due to autopsy-confirmed FTLD-tau, we characterized neuropsychiatric symptoms at early and late disease stages and determined whether the presence of certain symptoms predicted a specific underlying FTLD-tauopathy. Cognitive decline in PPA and bvFTD is often accompanied by debilitating neuropsychiatric symptoms. 4Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United Statesįrontotemporal lobar degeneration (FTLD) with tau pathology (FTLD-tau) commonly causes dementia syndromes that include primary progressive aphasia (PPA) and behavioral variant frontotemporal dementia (bvFTD).3Department of Preventative Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.2Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.

1Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.Rachel Keszycki 1,2 *, Allegra Kawles 1,2, Grace Minogue 1, Antonia Zouridakis 1, Alyssa Macomber 1,2, Nathan Gill 1,3, My Vu 1, Hui Zhang 1,3, Christina Coventry 1, Emily Rogalski 1, Sandra Weintraub 1,2, M-Marsel Mesulam 1, Changiz Geula 1,4 and Tamar Gefen 1,2

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